The objectives of the study were (1) To evaluate the safety and tolerability of Damtab. (2) Tocharacterize hypoglycemic effect of Damtab, if any. (3) To evaluate insulin sensitivity effect ofDamtab, if any. Hypoglycemic effect of Damtab (700 mg and 1,400 mg) were examined. Gliclazide(80 mg) was used as an active control. Placebo was used as control. Breakfast was given, half anhour before dosing whereas lunch, snacks and dinner were given at 6, 10 and 14 h post dose. Anoral glucose tolerance test was conducted to calculate the insulin sensitivity index from the valuesof glucose and insulin during oral glucose tolerance test. Both giclazide 80 mg and Damtab 1,400mg significantly lowered plasma glucose level up to 6 h. Insulin sensitivity index of Damtab(1,400 mg) was found to be similar to that of placebo. A significant increase in insulin level at 1 hpost dose of Damtab (1,400 mg) was observed. Damtab 700 mg shows placebo like effect whereasDamtab 1,400 mg possesses hypoglycemic effect.