Effects of amygdalin on the functional recovery and c-Fos expression inthe ventrolateral periaqueductal gray region after sciatic crushed nerveinjury in rats > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2008

Journal: Pages 556-563

February 2008 | Effects of amygdalin on the functional recovery and c-Fos expression inthe ventrolateral periaqueductal gray region after sciatic crushed nerveinjury in rats…

Toung-Wook Kim1, Hyung-Ho Lim1, Yun-Kyung Song1, Sung-Eun Kim2, Jin-Woo Lee2, Myoung-Hwa Lee2, Jin-Hee Seo2, Mal-Soon Shin2, Baek-Vin Lim3 and Chang-Ju Kim2,*

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Summary

​Peripheral nerve injuries are a commonly encountered clinical problem and often result in achronic pain and severe functional deficits. The expression of c-Fos is sometimes used as a markerof increased neuronal activity. We have prepared the aqueous extract of amygdalin fromArmeniacae semen for pain control. In the present study, we investigated the effects of amygdalinon the recovery rate of the locomotor function and on the expression of c-Fos in the ventrolateralperiaqueductal gray (vlPAG) region following sciatic crushed nerve injury in rats. Walking trackanalysis for the evaluation of functional recovery and immunohistochemistry for the c-Fosexpression were used in this study. In the present results, characteristic gait change withdropping of the sciatic function index (SFI) was observed and c-Fos expression in the vlPAG wassuppressed following sciatic crushed nerve injury in rats. Amygdalin enhanced SFI value andrestored c-Fos expression in the vlPAG to the control value. The present our study indicated thatamygdalin activates neurons in the vlPAG, and it facilitates functional recovery followingperipheral nerve injury


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