Puerariae flos inhibits inflammatory responses in interferon-γ andlipopolysaccharide-stimulated mouse peritoneal macrophages > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2007

Journal: Pages 229-234

September 2007 | Puerariae flos inhibits inflammatory responses in interferon-γ andlipopolysaccharide-stimulated mouse peritoneal macrophages…

Seung-Heon Hong1, Hoon-Jeon2, Dong-Seok Cha2, Ju-Young Lee3 and Ho-Jeong Na2,*

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Summary

​In macrophages, nitric oxide (NO) is released as an inflammatory mediator and has been proposed to bean important modulator of many pathophysiological conditions including inflammation. In thisstudy, we have examined the inhibition effects of NO production by 85% methanol extract of theflower of Pueraria thunbergiana (PF) in mouse macrophages. Extract of PF (1, 10, 100 µg/ml)inhibited NO production, inducible NO synthase and cyclooxygenase-2 expression in interferon-g and lipopolysaccharide-stimulated mouse peritoneal macrophages and it had no cytotoxicity.These data suggest that 85% methanol extract of PF might be useful in controlling macrophagesmediated inflammatory disease.


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