Effect of Ichnocarpus frutescens extract on antihyperglycemic, antihyperlipidemicand antioxidant status in streptozotocin-induced diabetic rats > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2007

Journal: Pages 244-253

September 2007 | Effect of Ichnocarpus frutescens extract on antihyperglycemic, antihyperlipidemicand antioxidant status in streptozotocin-induced diabetic rats…

Deepak K Dash1,3, Tirtha Ghosh2, Veerendra C Yeligar3, K Murugesh3, Siva S Nayak1, Bhim C Maiti3and Tapan K Maity3,*

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Summary

​The present study was carried out to investigate the antihyperglycemic, antihyperlipidemic andantioxidant effect of chloroform and methanol extract of whole plant of Ichnocarpus frutescens(CEIF and MEIF) in streptozotocin (STZ)-induced diabetic rats. Administration of CEIF and MEIForally at the dose of 200 mg/kg and 400 mg/kg body weight resulted in significant (P < 0.01) reductionin blood glucose levels. The body weights were significantly (P < 0.001) reduced in STZ-induced diabeticrats when compared to normal rats while the extracts significantly (P < 0.01) prevented the decrease inbody weight in the CEIF and MEIF treated rats. The study was further undertaken to evaluate theantioxidant and antihyperlipidemic potential of CEIF and MEIF in STZ-induced diabetic rats. Theincreased levels of lipid peroxidation in the liver tissues of diabetic rats were significantly reverted backto normal levels and a significant increase in the activity of antioxidant enzymes such as superoxidedismutase, catalase and the level of reduced glutathione in the liver of diabetic rats after the treatmentwith CEIF and MEIF was noticed. These results clearly indicate that CEIF and MEIF exhibit significantantihyperglycemic, antihyperlipidemic and in vivo antioxidant activity in STZ-induced diabeticrats and the results were found to be in a dose dependent manner.


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