Screening of Alstonia scholaris Linn. R. Br., for wound healing activity > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2007

Journal: Pages 254-260

September 2007 | Screening of Alstonia scholaris Linn. R. Br., for wound healing activity…

Arulmozhi S1,*, Rasal VP2, L Sathiyanarayanan3 and Purnima Ashok1

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Summary

​Alstonia scholaris (Family: Apocynaceae) has been indicated for the treatment of various diseases,one among which is wound healing. The purpose of this study is to investigate the woundhealing effect and antioxidant role of Alstonia scholaris leaves in animal models. The ethanol andaqueous extracts of Alstonia scholaris (EEAS, AEAS respectively) were tested against excision,incision and dead space wound models to evaluate the wound healing activity. In excisionwound model, treatment was continued till the complete healing of wound, in incision and deadspace wound models, the treatment was continued for 10 days. For topical application, 5% w/wointment of EEAS and AEAS were prepared in 2% sodium alginate. For oral administration, EEASwas suspended in distilled water using Tween 80 and AEAS was dissolved in distilled water. Thewound healing was assessed by the rate of wound contraction, period of epithelialisation, skinbreaking strength, granulation strength, dry granulation tissue weight, hydroxyproline, collagen andhistopathology of granulation tissue. Malondialdehyde level was also estimated to evaluate theextent of lipid peroxidation. AEAS and EEAS significantly promoted wound healing activity in allthe wound models studied. Increase in the rate of wound contraction, skin breaking strength,granulation strength, dry granulation tissue weight, hydroxyproline and collagen, decrease in theperiod for epithelialisation and increased collagenation in histopathological section wereobserved with EEAS and AEAS treated groups. EEAS and AEAS also significantly decreased thelevels of lipid peroxidation. The present study is suggestive that EEAS and AEAS promotewound healing activity.


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