Antihypertensive activity of Zingiber officinale and Korean ginseng inexperimentally induced hypertension in rats > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2007

Journal: Pages 261-273

September 2007 | Antihypertensive activity of Zingiber officinale and Korean ginseng inexperimentally induced hypertension in rats…

M Mohan1,*, R Balaraman2 and SB Kasture3

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Summary

​We investigated the antihypertensive effect of Pet ether extract (PE) of ginger rhizome; its toluenefraction (TF) and Korean ginseng extract (KGE) in deoxycorticosterone acetate (DOCA) – saltinduced and fructose induced hypertensive rats. In DOCA model, DOCA (25 mg/kg, once aweek; s.c) was administered in uninephrectomised animals for 4 w. PE (50 mg/kg/day; p.o), TF(10 mg/kg/day; p.o) and KGE (30 mg/kg/day; p.o) were evaluated for their antihypertensiveeffect. In the fructose model, drinking water was replaced with fructose (10%) for five weeks toinduce hypertension. PE (50 mg/kg/day; p.o) and KGE (30 mg/kg/day; p.o) were assessed for itsantihypertensive effect in fructose model. After completion of the treatment schedule, vascularreactivity to various agonists like 5-HT, noradrenaline, adrenaline, phenylbiguanide and acetylcholinewere recorded in rats of both the models. A cumulative dose response curve (CDRC) of 5-HT wascarried out in isolated rat fundus strip of the fructose induced hypertensive rats. Chronicadministration of PE (50 mg/kg/day; p.o), TF (10 mg/kg/day; p.o), and KGE (30 mg/kg/day; p.o)significantly reduced the blood pressure in DOCA salt whereas PE (50 mg/kg/day; p.o) and KGE (30mg/kg/day; p.o) reduced the blood pressure in fructose induced hypertensive rats. Treatment withPE (50 mg/kg/day; p.o) and KGE (30 mg/kg/day; p.o) in fructose model for five weeks shifted theCDRC towards the right on rat fundus. The mechanism of action may partly involve theserotonergic antagonistic property.


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