Effect of various fractions of Bacopa monnieri Linn. aerial parts on ethanol-induced hepatotoxicity in rats > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2007

Journal: Pages 297-303

September 2007 | Effect of various fractions of Bacopa monnieri Linn. aerial parts on ethanol-induced hepatotoxicity in rats…

Tirtha Ghosh1,*, Tapan Kumar Maity2, Deepak Kumar Dash2 and Anindya Bose1

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Summary

​The ethyl acetate fraction (EAF) and n-butanol fraction (NBF) of ethanolic extract of Bacopa monnieriaerial parts were screened for hepatoprotective activity and in vivo antioxidant activity on ethanol-induced hepatotoxic rats. Ethyl acetate fraction was found to be more potent even though both thefractions were endowed with significant hepatoprotective activity. EAF and NBF were investigatedfor hepatoprotective activity in albino rats at 300 mg/kg, p.o. dose and compared with standard drugSilymarin (25 mg/kg, p.o.). Results show that both the fractions were effective in blunting ethanol-induced enhanced activities of serum glutamate oxaloacetate transaminase, serum glutamatepyruvate transaminase, alkaline phosphatase, level of serum bilirubin (both total and direct), liverweight loss and was also effective in reducing ethanol–induced lipid peroxidation both in vitro and invivo. Furthermore, the fractions could also enhance ethanol-induced suppressed activities ofsuperoxide dismutase, catalase and decreased level of reduced glutathione. Results of hepatocellulardamage caused by ethanol and its recovery by EAF and NBF, suggest that they might be considered asa potential source of natural hepatoprotective agents, which could be related to the free radicalscavenging properties of saponins present in high concentration in the fractions.


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