Ethanol extract of Callophyllis japonica enhances nitric oxide and tumornecrosis factor-alpha production in mouse macrophage cell line, RAW 264.7cells > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2007

Journal: Pages 341-347

December 2007 | Ethanol extract of Callophyllis japonica enhances nitric oxide and tumornecrosis factor-alpha production in mouse macrophage cell line, RAW 264.7cells…

Meejung Ahn1,2,3, Dal-Soo Park1, Won-Hyung Yang1, Gyung-Min Go4, Hyung-Min Kim5, Jin-Won Hyun2,6, Jae-Woo Park7 and Taekyun Shin1,2,3,*

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Summary

​Red seaweed (Callophyllis japonica) has long formed part of the diet of Asians, but thepharmacological properties of this plant have not been evaluated. In this study, we examined theeffect of an ethanol extract of C. japonica on the generation of nitric oxide (NO) in RAW 264.7 cells.The C. japonica extract increased the generation of NO and tumor necrosis factor-α (TNF-α), whichwere detected by the Griess method and an enzyme-linked immunosorbent assay, respectively. Theincreased production of NO by C. japonica extract was inhibited by NG-monomethyl-L-arginine(100 μM), a specific inhibitor of NO production in the L-arginine-dependent pathway, and by thenuclear factor-κB (NF-κB) inhibitor, pyrrolidine dithiocarbamate (10 - 100 μM) in a dose-dependentmanner. These findings demonstrate that C. japonica extract stimulates the production of NO and TNF-αin RAW 264.7 cells through the activation of NF-κB and that this extract might also inhibit the growth ofthe human leukemic cells.


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