We undertook the present study to evaluate different pharmacological as antioxidant, antibacterial andcytotoxic activities of the crude ethanolic extract of Momordica charantia (Family: Cucurbitaceae)leaves. The antioxidant property of the extract was assessed by 1, 1-diphenyl-2-picryl hydrazylfree radical scavenging assay. The extract showed antioxidant activity where IC50 was about~500 µg/ml and IC50 was about ~10 µg/ml for standard drug ascorbic acid. The extract showed abroad spectrum of antibacterial activity against all the tested gram positive and gram-negativebacteria where Staphylococcus epidermidis, Staphylococcus aureus, Salmonella typhi and Shigelladysenteriae were prominent. And the zones of inhibition were ranging from 8 - 15 mm for all thetested bacteria. Its cytotoxic property was evaluated by brine shrimp lethality bioassay. Theextract showed significant lethality and the LC50 value was 20 µg/ml.