Evaluation of analgesic and antiinflammatory activity of Ophiorrhizanicobarica, an ethnomedicine from Nicobar Islands, India > Volume 07 - 2007

본문 바로가기

사이트 내 전체검색


 » New Articles(2011~Present)
 » Articles (2001~2010)
      ∙ Volume 10 - 2010
      ∙ Volume 09 - 2009
      ∙ Volume 08 - 2008
      ∙ Volume 07 - 2007
      ∙ Volume 06 - 2006
      ∙ Volume 05 - 2005
      ∙ Volume 04 - 2004
      ∙ Volume 03 - 2003
      ∙ Volume 02 - 2002
      ∙ Volume 01 - 2001
 

Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2007

Journal: Pages 395-408

December 2007 | Evaluation of analgesic and antiinflammatory activity of Ophiorrhizanicobarica, an ethnomedicine from Nicobar Islands, India…

Debprasad Chattopadhyay1,*, Sonali Das2, Asit Baran Mandal2, G Arunachalam1 and SKBhattacharya1

첨부파일

Summary

​This study reports the analgesic, anti-inflammatory and membrane-stabilizing property of alcoholicextract of Ophiorrhiza nicobarica (ON), a wild herb, used as an anti-infective ethnomedicine ofNicobarese and Shompen tribes of Great Nicobar Island, India. We for the first time investigated theanalgesic and antiinflammatory potential of this herb in acute, subacute and chronic model ofinflammation in Swiss albino mice and Wistar albino rats, along with sheep RBC-induced sensitivityand membrane stabilization. The acetic acid induced writhing, tail flick and tail immersion tests areused as a model for evaluating analgesic activity; while the carrageenin-induced paw oedema wasused as the model for acute inflammation, dextran-induced oedema as sub-acute and cotton-pellate-induced granuloma as chronic inflammatory model. The probable mode by which ON mediate itseffect on inflammatory conditions was studied on sheep RBC-induced sensitivity and membranestabilization. The in vitro results revealed that the ON extract possesses significant (P < 0.05) dosedependent analgesic and antiinflammatory activity at 200 and 300 mg/kg and its fractions at 50 mg/kg, p.o. respectively, compared to the control groups. However, the extract failed to exhibitmembrane-stabilizing property as it unable to reduce the level of haemolysis of RBC exposed tohypotonic solution. The acute toxicity studies of ON extract in rats and mice revealed that the extractwas nontoxic even up to 3.0 g/kg body weight of the animals, with a high safety profile. We haveisolated ursolic acid, β-sitosterol and harmaline respectively, from the bioactive part of the extract. Theresults indicated that the O. nicobarica is indeed beneficial in primary health care, and suggest that itsanti-inflammatory activity may not be related to membrane-stabilization.


This website Copyright (c) 2014 Institute of Korean Medicine Kyung Hee University All rights reserved.
Top View
Mobile View