The study was to evaluate the antihyperglycemic activity of Biophytum sensitivum (L.) DC indifferent extracts. Albino Wistar rats with alloxan hydrate induced diabetes were divided into 7groups of 6 each. Both aqueous and methanolic extract of Biophytum sensitivum were preparedand given individually at different doses to different batches of rats (both normal and diabeticrats) after an overnight fast. Methanolic extract at the dose of 200 mg/kg body weight showedmaximum blood glucose lowering effect in diabetic rats. The same dosages did not produce anyhypoglycemic activity in normal rats. The antihyperglycemic activity of Biophytum sensitivum wascompared with a standard drug Glibenclamide, an oral hypoglycemic agent. The above resultssuggest that maximum hypoglycemic effect was found only with a dose of up to 200 mg/kg b.w.of methanolic extract which is therefore the optimum dose for hypoglycemia and was used in allthe experiments of the present study.