Antinociceptive and anti-inflammatory activities of Pandanus fascicularisLamk. leaves in animal models > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2008

Journal: Pages 485-493

February 2008 | Antinociceptive and anti-inflammatory activities of Pandanus fascicularisLamk. leaves in animal models…

Prabhudutta Panda1, DP Panda1, PK Panda2 and SS Nayak1,*

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Summary

​The present study was carried out to elucidate the potential of, chloroform extract of Pandanus (P.)fascicularis Lamk (Family-Pandanaceae) leaves on antinociceptive, behavioral study and anti-inflammatory effects using various animal models The dried, powdered leaves of, P. fasciculariswere extracted successively with petroleum ether (60 - 80°C) and chloroform in soxhlet apparatus.The chloroform extract (yield 21.6% w/w with respected to dry powdered plant material) wasselected for all experimental procedure. Two models were employed to investigate the effects onnociception, the tail immersion and hot plate method in Swiss albino mice and anti inflammatoryeffect were investigated by employing the carrageenan induced rat paw edema test in. adultWister albino rats. Behavioral study was investigated by elevated plus maze method in Swissalbino mice. Results were revealed that the PFCE was found significant antinociceptive effect (P <0.001) at the dose levels of 100, 200 and 400 mg/kg, orally in mice and produced remarkable anti-inflammatory effect (P < 0.001) at the same dose levels used in the rats. Behavioral study of the PFCEhas no significant anxiolysis effect when used orally. It concludes that, PFCE possessed remarkableantinociceptive effect and anti-inflammatory effect but no anxiolytic effect on animal models.


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