Effects of Gyejijakyakjimo-tang extract on inhibition of PGE2 synthesis andNO production in murine raw 264.7 macrophage cells > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2008

Journal: Pages 509-517

February 2008 | Effects of Gyejijakyakjimo-tang extract on inhibition of PGE2 synthesis andNO production in murine raw 264.7 macrophage cells…

Kyoung-Su Park, Mi-Ja Hwang, Ki-Bong Nam, Ji-Mi Ryu and Seok-Hee Chung*

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Summary

​Gyejijakyakjimo-tang is a multi-herbal formula that is composed of nine medicinal herbs.Gyejijakyakjimo-tang has been reported to have antipyretic and analgesic effects. Gyejijakyakjimo-tanghas traditionally been used for goat and rheumatoid arthritis. However, analgesic and anti-inflammatory effects of Gyejijakyakjimo-tang has not been clarified yet. In this study, weinvestigated the analgesic and anti-inflammatory effect of the aqueous extract of Gyejijakyakjimo-tang. Weevaluated the aqueous extract of Gyejijakyakjimo-tang on Lipopolysaccharide (LPS)-inducedinflammation in murine raw 264.7 macrophage cells. For this study, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction(RT-PCR), prostaglandin E2 (PGE2) immunoassay, and nitric oxide (NO) detection wereperformed. Gyejijakyakjimo-tang suppressed PGE2 synthesis and NO production by inhibiting theLPS-induced expressions of COX-2 and iNOS mRNA in murine raw 264.7 macrophage cells.These results show that Gyejijakyakjimo-tang has the analgesic and anti-inflammatory effect bymostly suppressing COX-2 and iNOS expressions, and resulting in the inhibition of PGE2synthesis and NO production.


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