Inhibitory effects of Gamichungsangbohatang on chemokines related asthmain A549 human epithelial cells > Volume 07 - 2007

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Oriental Pharmacy and Experimental Medicine
Volume 07 - 2007
Date: 2008

Journal: Pages 518-526

February 2008 | Inhibitory effects of Gamichungsangbohatang on chemokines related asthmain A549 human epithelial cells…

Seung-Yeon Jeong, Sung-Hun Lee, Young-Lae Roh, Jae-Hwan Kim, Hee-Jae Jung and Sung-Ki Jung*

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Summary

​Recently a major goal in asthma therapy is to reduce or prevent the inflammatory response ofairway. Eosinophilic accumulation in the tissue is a prominent feature of allergic diseasesincluding asthma. Production of chemokines by bronchial epithelial cells may contribute to theallergic inflammation by recruiting eosinophils. In this study we evaluated the inhibitory effect ofGamichungsangbohatang (GMCSBHT), used traditionally in treating asthma, on secretion ofchemokines for eosinophils in human A549 epithelial cells. Chemokines such as eotaxin, RANTES, IL-8 were inhibited in a dose-dependent manner, but IL-16 showed no inhibition by GMCSBHT. Thesefindings indicate that GMCSBHT might be a therapeutic value in treating asthma by suppression ofchemokines secretion associated with local accumulation of eosinophils.


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