Pharmacological and Biochemical studies on Telescopium telescopium – amarine mollusk from the Mangrove regions > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: October 18, 2007

Journal: Pages 386-394

December 2008 | Pharmacological and Biochemical studies on Telescopium telescopium – amarine mollusk from the Mangrove regions…

SK Samanta1, D Adhikari1, S Karmakar1, A Dutta1, A Roy1, KT Manisenthil1, D Roy1, JR Vedasiromoni2and T Sen1,*

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Summary

​The tissue extract (TTE) of a marine snail Telescopium telescopium, collected from the coastalregions of West Bengal, India, was extensively screened for pharmacological and biochemicalproperties. Telescopium telescopium (TTE) produced significant lysis of washed rat erythrocytes(both direct and indirect), produced haemorrhagic lesions in the skin and also releasedhaemoglobin (in vitro tissue damage) from different tissue samples. TTE was found to producepro-inflammatory effects when injected into the rat hind paw and also increased peritonealvascular permeability. Furthermore, intravenous administration of TTE produced a decrease inblood pressure (hypotensive effect) in anaesthetized rats. The extract produced potent esteraseactivity, as was evident from the breakdown of FDA with subsequent release of fluorescein (in vitro).TTE also demonstrated prominent cholinesterase, phospholipase, phosphatase and proteaseactivities.


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