The aim of the present study is to investigate the anti-inflammatory and antimicrobial activity ofpetroleum ether and ethanol extracts of Scutia myrtina (Family: Rhamnaceae). In anti-inflammatory activity carrageenan and histamine induced paw oedema and cotton pellet inducedgranuloma for acute and chronic inflammatory models were studied in Wister albino rats. Basedon the results of the present study it can be concluded that petroleum ether and ethanol extract ofScutia myrtina at 400 mg/kg has potential anti-inflammatory effect and they act in a dosedependent manner. Both extracts of Scutia myrtina showed antimicrobial activity against allbacterial and fungal strains tested at the concentration of 100 µg/ml. From the result, it can beconcluded that the Scutia myrtina contain antibacterial and antifungal principle. Further more,besides the confirmation of the popular use; the obtained results demonstrate this herbal drug torepresent a new source of antimicrobial and anti-inflammatory agent.