Search towards an insight for comparative anti-tumour effects of Wrightiatomentosa leaf & bark in ehrlich ascites carcinoma bearing mice > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: November 21, 2007

Journal: Pages 408-415

December 2008 | Search towards an insight for comparative anti-tumour effects of Wrightiatomentosa leaf & bark in ehrlich ascites carcinoma bearing mice…

K Nagarajan1,*, Avijit Mazumder2 and LK Ghosh3

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Summary

​In the present study, the ethanolic leaf and bark extract of Wrightia tomentosa were tested forcomparative in vivo antitumour properties against Ehrlich ascites carcinoma (EAC) tumourbearing mice at 100 and 200 mg/kg body weight doses given orally once daily for 16 days. TheEAC mice receiving 100 and 200 mg/kg ethanolic leaf and bark extract showed a dose dependentelevation in tumour – free survival and a highest number of survivors were observed at 200 mg/kg for leaf extract of ethanol, which was considered as an optimum dose for its anti neoplasticaction. The Median survival time for this dose was approximately 44 days when compared with23 days of non-drug treated controls. The results indicate that the administration of leaf extractnot only increased the survival of animals with ascites tumour and reduced packed cell volumeand viable tissue cell count, but also altered many hematological parameters changed duringtumour progression, indicating the potent antitumour nature of leaf extract than the bark extract.Statistical analysis also reveals that the leaf extract showed highly significant anti tumour potency(p < 0.001) when compared with control.


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