Study on diuretic activity and electrolytes excretion of methanol extract ofLippia nodiflora (Verbenaceae) in rats > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: 2008

Journal: Pages 39-46

March 2008 | Study on diuretic activity and electrolytes excretion of methanol extract ofLippia nodiflora (Verbenaceae) in rats…

Ashok kumar D1,*, Senthilkumar GP1, Thamil selvan V1, Mazumder UK1, Gupta M1 and Ray SK2

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Summary

​In the Indian traditional medicine, Lippia nodiflora (Verbenaceae) whole plant is claimed to possesspowerful diuretic activity. However, the diuretic potential of this plant is not yet investigated.The aim of this study was to evaluate the diuretic potential of methanol extract of Lippia nodiflora(MELN) in rats. Control (0.9% saline solution, 25 ml/kg, b.w) or urea (1 g/kg b.w) or frusemide (5 mg/kgb.w) and different concentrations of MELN (200 and 400 mg/kg b.w) were intraperitoneallyadministered (n=6 per each treatment group) to hydrated rats and their urine output wasmonitored over a period of 5 h and 24 h after drug administration. The diuretic responses with itselectrolyte excretion potency of the extract were highly remarkable in comparison with controlanimals. The extract at doses of 200 and 400 mg/kg shows a significant increase in volume ofurine with increase in Na+, Ca2+ and Cl- excretion accompanied by the excretion of K+ in dosedependent manner. This study suggests that the active component(s) in MELN had similardiuretic effect to that of frusemide. These results validate the traditional use of Lippia nodiflora as adiuretic agent.


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