The plant Quisqualis indica (Compositae) has ehnopharmcological reputation of being used as ahealing agent in Bangladesh. In this study, preliminary screenings were conducted to look at theantimicrobial susceptibility and cytotoxicity of the plant extract. The extractives of the plant weresubjected to screening for inhibition of microbial growth by the disc diffusion method. The zonesof inhibition demonstrated by the n-hexane, carbon tetrachloride, chloroform and aqueoussoluble partitionates of the methanolic extract ranged from 8 - 15 mm, 8 - 18 mm, 12 - 20 mm and10 - 16 mm, respectively at a concentration of 400 µg/disc. All the extractives were also subjectedto brine shrimp lethality bioassay for primary cytotoxicity evaluation. Here, the carbontetrachloride soluble materials demonstrated the highest cytotoxicity with LC50 of 0.826 µg/ml,while n-hexane, chloroform and aqueous soluble partitionates of the methanolic extract revealedthe LC50 of 1.254, 3.866 and 5.366 µg/ml, respectively. This is the first report of the antimicrobialactivity and cytotoxicity Q. indica.