The aim of the study was to evaluate in vitro antioxidant and cytotoxic activities of the methanolicextracts of leaves of Solanum sisymbrifolium, Solanum anguivi multiflora, Solanum barbisetum and Solanumjasminoides. In the in vitro antioxidant screening using ABTS [2,2’-azino-bis (3-ethylbenzo-thiazoline-6-sulphonic acid) diammonium salt] method, the methanol extracts of Solanum jasminoides, Solanumbarbisetum and Solanum anguivi multiflora exhibited potent antioxidant activity with IC50 values 31.25 ±0.35, 40.33 ± 0.57 and 54.33 ± 0.57 µg/ml, respectively. Solanum barbisetum also showed potent activityin DPPH [1,1-diphenyl-2-picryl hydrazyl] method with an IC50 value of 55.33 ± 1.66 µg/ml. In thecytotoxicity studies, the methanol extract of Solanum barbisetum exhibited moderate activity againstVero, HEp-2, HeLa and A-549 cell lines with IC50 values in the range of 83.30 - 127.30 µg/ml. Solanumanguivi multiflora extract also showed moderate activity against Hep-2 cell line with IC50 value of 80.13µg/ml. Solanum barbisetum possessing both the activities requires further investigation.