Phytochemical and biological investigations of Polygonum lanatum > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: 2008

Journal: Pages 97-102

March 2008 | Phytochemical and biological investigations of Polygonum lanatum…

Sadia A Chowdhury1,2, Mohammad H Sohrab3, Mohammad R Haque1, Choudhury M Hasan1 andMohammad A Rashid*,1,2

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Summary

​A total of five compounds namely, 2-methylanthracene-9, 10-dione (1), 1-hydroxy-6-methylanthracene-9,10-dione (2), β-sitosterol (3), stigmasterol (4) and sitosterone (5) were isolatedfrom the stem extracts of Polygonum lanatum for the first time. The structures of the isolatedcompounds (1-5) were established by extensive spectroscopic studies, including 2D NMR such as1H-1H COSY, HSQC and HMBC studies. The crude extracts and purified compound (1) werescreened for antimicrobial activity against a wide range of Gram-positive and Gram-negativebacteria and fungi by the disc diffusion method. The n-hexane and dichloromethane solublepartitionates of the methanolic extract revealed mild to moderate inhibition of growth of the testorganisms. The cytotoxic potential of the extractives and compound 1 was also determined byusing brine shrimp lethality bioassay, where the extractives demonstrated significant cytotoxicactivities.


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