Screening of KMU-4, 6, 7 on inflammatory responses in IFN-γ and LPS-induced mouse peritoneal macrophages > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: March 07, 2008

Journal: Pages 125-129

June 2008 | Screening of KMU-4, 6, 7 on inflammatory responses in IFN-γ and LPS-induced mouse peritoneal macrophages…

Ho-Jeong Na1, Hyun-Ja Jeong2, Jong-Woong Ahn3, Jae-Young Um4, Hyung-Min Kim4 and Seung-HeonHong1,*

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Summary

​Korean Marine Plants (KMU-4, 6, 7) obtained from an herb which widely used in medicine for thetreatment of a variety of pathologies. In this study, using mouse peritoneal macrophages, we haveexamined whether KMU-4, 6, 7 affects nitric oxide (NO) and COX-2 induced IFN-γ and LPS andcell viability. KMU-6 inhibits IFN-γ and LPS-induced NO. We found that KMU-6 had a little effecton COX-2 expression. These finding means that KMU-6 can be used in controlling macrophagesmediated inflammatory disease. The present results indicate that KMU-6 has an inhibitory effecton the production of NO through down-regulation of COX-2 expression in LPS stimulated mouseperitoneal macrophages.


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