Ayurveda, an ancient System of Indian Medicine, has recommended a number of drugs fromindigenous plant sources for the treatment of inflammation. To evaluate the anti-inflammatory andanalgesic activities of methanol extract of Triphala were investigated in Wister albino rats and mice.The methanol extract of Triphala were found to encompass substantial anti-inflammatory effect inacute and sub-acute models and analgesic effect. Animal models of carrageenan induced edemaand cotton pellet induced granuloma in albino rats were used. Extract of 200 mg/kg showssignificantly reduced paw edema. Analgesics activity of Triphala with 200 mg/kg shown bysignificant reduction of writhing. These report shows to support the use methanol extract ofTriphala in relieving inflammation and pain.