Silymarin, a flavonoid antioxidant, protects streptozotocin-induced lipidperoxidation and β-Cell damage in rat pancreas > Volume 08 - 2008

본문 바로가기

사이트 내 전체검색


 » New Articles(2011~Present)
 » Articles (2001~2010)
      ∙ Volume 10 - 2010
      ∙ Volume 09 - 2009
      ∙ Volume 08 - 2008
      ∙ Volume 07 - 2007
      ∙ Volume 06 - 2006
      ∙ Volume 05 - 2005
      ∙ Volume 04 - 2004
      ∙ Volume 03 - 2003
      ∙ Volume 02 - 2002
      ∙ Volume 01 - 2001
 

Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: January 15, 2007

Journal: Pages 146-153

June 2008 | Silymarin, a flavonoid antioxidant, protects streptozotocin-induced lipidperoxidation and β-Cell damage in rat pancreas…

Manju Sharma1,*, Tarique Anwer1, K K Pillai1, Syed Ehtaishamul Haque1, A K Najmi1and YasminSultana2

첨부파일

Summary

​The present study is aimed at finding the influence of silymarin (a flavonoid) (25 mg/kg & 50 mg/kg) instreptozotocin (STZ)-induced diabetic rats. Type 2 diabetes was induced by single intraperitonealinjection of STZ (100 mg/kg) to 3 days old rat pups. Silymarin was administered for 15 days afterthe animals were confirmed diabetic (75 days after STZ injection). Blood glucose, glycosylatedhemoglobin (HbA1c), lipid peroxides (LPO) levels and reduced glutathione (GSH) contents inpancreas and liver were estimated following the established procedures. Biochemical observations werefurther substantiated with histological examination of pancreas. Blood glucose and HbA1c levels, whichwere elevated by STZ, were lowered to physiological levels by the administration of silymarin. Thelevels of LPO were significantly increased in STZ-induced diabetic rats. Silymarin reduced the LPOlevels in both pancreas and liver. GSH contents which were reduced significantly in pancreas andliver of STZ-induced diabetic rats were brought back to near normal levels by silymarin treatment.Multifocal necrotic and degenerative changes of pancreas in STZ-diabetic rats were minimized to nearnormal morphology by administration of silymarin as evident by histopathological examination.Silymarin showed a dose dependent protective effect on STZ-induced β-cell damage. It could beattributed to the antioxidative and free radicals scavenging properties of the flavonoid. Thus, itmay be considered as a natural antioxidant with potential therapeutic application in the treatmentof type 2 diabetes.


This website Copyright (c) 2014 Institute of Korean Medicine Kyung Hee University All rights reserved.
Top View
Mobile View