Antitumor effect of Careya arborea against Ehrlich ascites carcinoma withreference to lipid peroxidation and enzymatic and non enzymatic antioxidantsystem in Swiss albino mice > Volume 08 - 2008

본문 바로가기

사이트 내 전체검색


 » New Articles(2011~Present)
 » Articles (2001~2010)
      ∙ Volume 10 - 2010
      ∙ Volume 09 - 2009
      ∙ Volume 08 - 2008
      ∙ Volume 07 - 2007
      ∙ Volume 06 - 2006
      ∙ Volume 05 - 2005
      ∙ Volume 04 - 2004
      ∙ Volume 03 - 2003
      ∙ Volume 02 - 2002
      ∙ Volume 01 - 2001
 

Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: January 26, 2007

Journal: Pages 154-163

June 2008 | Antitumor effect of Careya arborea against Ehrlich ascites carcinoma withreference to lipid peroxidation and enzymatic and non enzymatic antioxidantsystem in Swiss albino mice…

R Sambath Kumar1,*, T Sivakumar1, V Senthil1, N Venkateswara Murthy1, V Balasubramaniam1,R Kanaga Sabi1, R. Shanmuga Sundram1, P Perumal1, U K Mazumder2 and M Gupta2

첨부파일

Summary

​The methanol extract of stem barks of Careya arborea Roxb. (MECA) (Family- Myrtaceae) wasevaluated for antitumor activity and antioxidant status against Ehrlich’s Ascites Carcinoma(EAC) bearing Swiss albino mice. After 24 h of tumor inoculation the MECA was administered atthe doses of 50, 100 and 200 mg/kg body weight/mice/day for 14 days. After the last dose and 18h fasting mice were sacrificed. The effect of MECA on the growth of transplantable murine tumor,life span of EAC bearing hosts, hematological profiles, serum and liver biochemical parameterswere estimated. The MECA showed significant (P < 0.01) decrease in ascites volume, packed cellvolume and viable cell count and prolonged the life span of EAC tumor bearing mice.Hematological profiles reverted to more or less normal levels in extract treated mice. The MECAalso produced protective effect by decreasing the activity of serum enzymes, bilirubin andincrease the protein and uric acid levels. MECA significantly (P < 0.05) decreased the levels oflipid peroxidation, while significantly (P < 0.05) increased the levels of glutathione content,vitamin C, vitamin E, superoxide dismutase and catalase CAT. The results indicate that MECAexhibited significant antitumor and antioxidant activity in EAC bearing mice.


This website Copyright (c) 2014 Institute of Korean Medicine Kyung Hee University All rights reserved.
Top View
Mobile View