The methanol extract of stem barks of Careya arborea Roxb. (MECA) (Family- Myrtaceae) wasevaluated for antitumor activity and antioxidant status against Ehrlich’s Ascites Carcinoma(EAC) bearing Swiss albino mice. After 24 h of tumor inoculation the MECA was administered atthe doses of 50, 100 and 200 mg/kg body weight/mice/day for 14 days. After the last dose and 18h fasting mice were sacrificed. The effect of MECA on the growth of transplantable murine tumor,life span of EAC bearing hosts, hematological profiles, serum and liver biochemical parameterswere estimated. The MECA showed significant (P < 0.01) decrease in ascites volume, packed cellvolume and viable cell count and prolonged the life span of EAC tumor bearing mice.Hematological profiles reverted to more or less normal levels in extract treated mice. The MECAalso produced protective effect by decreasing the activity of serum enzymes, bilirubin andincrease the protein and uric acid levels. MECA significantly (P < 0.05) decreased the levels oflipid peroxidation, while significantly (P < 0.05) increased the levels of glutathione content,vitamin C, vitamin E, superoxide dismutase and catalase CAT. The results indicate that MECAexhibited significant antitumor and antioxidant activity in EAC bearing mice.