Analgesic and antidiarrhoeal activities of Treama orientalis Linn. in mice > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: May 18, 2007

Journal: Pages 187-191

June 2008 | Analgesic and antidiarrhoeal activities of Treama orientalis Linn. in mice…

Sarder Nasir Uddin1,*, Khan Mohammad Ahsan Uddin1 and Firoz Ahmed2

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Summary

​Trema orientalis Linn. is commonly grown in many parts of Bangladesh. Its leaves have been used foranalgesic and anti-diarrhoeal activity in traditional medicine. This study evaluates the potentialanalgesic and anti-diarrhoeal activity of methanol and aqueous extracts of leaves in experimental aceticacid induced writhing and castor oil induced diarrhoea in mice. The aqueous extract of leaves showedsignificant (P < 0.001) analgesic effect in acetic acid induced writhing in mice at a dose of 500 mg/kgbody weight In castor oil induced antidiarrhoeal screening both extract increased latent period (P <0.025) and decrease the number of stool (P < 0.025) at the dose of 500 mg/kg body weight comparablewith that of the standard drug loperamide. The results provide a support for the use of this plant intraditional medicine and suggest its further investigation.


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