The methanol extract of the root of Artanema sesamoides Family Scrophuilariaceae (MEAS) wasinvestigated for possible analgesic and anti-inflammatory effects in animals. Three models wereused to study the extract effects on nociception, which were acetic acid-induced writhingresponse, hot-plate method and the tail flick test in mice. The antiinflammatory effects wereevaluated using carrageenan, dextran, histamine and serotonin induced rat paw oedema (acute)and cotton pellet induced granuloma (chronic) models in rats. Results of the study revealed thatthe extract exhibited significant (P < 0.001) analgesic effect at a dose of 50, 100 and 200 mg/kg b.wp.o in mice in all the models. In acute model, the MEAS also exhibited significant (P < 0.001)antiinflammatory effect in all the above mentioned doses. In chronic model (cotton pellet inducedgranuloma) the MEAS 200 mg/kg and indomethacin 10 mg/kg showed that inhibition ofgranuloma formation 25.0% and 47.7% respectively (P < 0.001). The MEAS and indomethacinwere effectively preventing the transudation of the fluid. Thus, the present study revealed thatthe methanol extract of the root of Artanema sesamoides exhibited significant analgesic andantiinflammatory activity.