Anti-inflammatory and anti-noceceptive action of the crude extracts of Costusspecious on rodents > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: March 14, 2007

Journal: Pages 243-251

September 2008 | Anti-inflammatory and anti-noceceptive action of the crude extracts of Costusspecious on rodents…

Md. Ashraful Alam1*, Nusrat Subhan2, Md. Abdul Awal3, Md. Shohidul Alam4 and Kazi Akramudaulla2

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Summary

​The effect of alcoholic extracts of Costus specious (Family: Zingiberaceae) was evaluated inexperimental models of pain and inflammation. Oral administration of 100, 200 and 300 mg/kg ofC. specious extracts were used for the above study. Crude extracts of C. specious (300 mg/kg dose)showed maximum time needed for the response against thermal stimuli (7.242 ± 0.532 s) which iscomparable to diclofenac sodium (8.471 ± 0.257 s) in the hot plate test. The MPH (MaximumPossible Analgesia) has been found to be 14.285 for 300 mg/kg dose of the crude extract while theMPH for diclofenac was 15.857 after 60 min of administration in the hot tail-flick method. Thecrude extract at 300 and 200 mg/kg doses showed significant reduction in acetic acid inducedwrithings in mice with a maximum effect of 59.661% reduction at 300 mg/kg dose which iscomparable to standard diclofenac sodium (73.4%). Alcoholic extract of C. specious showedsignificant inhibition in serotonin and egg albumin induced hind paw oedema in rats at 100, 200and 300 mg/kg of the crude extracts respectively (Serotonin induced edema 44.22; 53.75; 58.51%;egg albumin induced edema - 41.317; 53.892; 59.880% inhibition after 4 h respectively). The anti-inflammatory effects showed by the extract were comparable to that of standard indomethacin5 mg/kg (Serotonin induced edema 77.56%; egg albumin induced edema 77.844% inhibition after4 h). These results suggest that the extract possesses both the anti-inflammatory and analgesicactivity on mice and rat model.


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