The chloroform extract of Croton roxburghii (Family: Euphorbiaceae) was evaluated for itsantipyretic effects in Brewer’s yeast induced hyperthermia in rats. The anti-inflammatory effect ofthe Croton roxburghii was also evaluated by using carrageenan, dextran, histamine, serotonininduced rat paw oedema and cotton pellet induced granuloma (chronic) models in rats. Thechloroform extract of Croton roxburghii (CECR) exhibited significant anti-pyretic and anti-inflammatory effect at the dose 50, 100 and 200 mg/kg. Maximum inhibition (55.32%) was notedat the dose of 200 mg/kg after 3 h of drug treatment in carrageenan induced paw oedema,whereas the Indomethacin (standard drug) produced 61.33% of inhibition. The extract exhibitedsignificant anti-inflammatory activity in dextran induced paw edema in a dose dependentmanner. In the chronic model (cotton pellet induced granuloma) the CECR (200 mg/kg) andIndomethacin (10 mg/kg) showed decreased formation of granuloma tissue by 52.32% and56.32% respectively. The extract also exhibited a significant antipyretic response in Brewer’s yeastinduced pyrexia in rats. Thus, the present study revealed that the CECR exhibited significantantipyretic and anti-inflammatory activity in the tested animal models.