Annona reticulata belonging to the family Annonaceae is traditionally used as anthelmintic and itis reported to have anticancer activity. Free radicals are known to be involved in various types ofdiseases like cancer, diabetes, neurological disorders etc. The present study was aimed to evaluatefree radical scavenging property of methanol extract of the leaves of Annona reticulata in some invitro models e.g. DPPH, nitric oxide, superoxide and lipid peroxide radical model. The extractshowed good dose-dependent free radical scavenging property in all the models. IC50 values werefound to be 3.22, 170.01, 25.12 and 140.12 µg/ml respectively in DPPH, nitric oxide, superoxideand lipid peroxidation inhibition assays. Reductive ability of the extract was also tested based onpotassium ferricyanide reduction where dose dependant reducing capability was observed.Measurement of total phenolic compounds by Folin-Ciocalteu’s phenol reagent indicated that1mg of the extract contained 146.20 µg equivalent of pyrocatechol. The findings ascertainpromising free radical scavenging property of the extract and the antioxidant property of theextract may be due to the high content of phenolic compounds.