Panax Ginseng inhibited HIF-1a activation and inflammatory cytokine inHMC-1 cells activated by phorbol myristate acetate and A23187 > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: October 08, 2008

Journal: Pages 440-447

December 2008 | Panax Ginseng inhibited HIF-1a activation and inflammatory cytokine inHMC-1 cells activated by phorbol myristate acetate and A23187…

In-Young Choi1, Hyun-Ja Jeong2, Hyo-Jin An3, Tae-Hee Kang3, Chul-Won Zo3, Bong-Keun Song4,Eun-Jeong Park4, Eun-Cheol Kim5, Jae-Young Um3, Hyung-Min Kim3, and Seung-Heon Hong1,*

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Summary

​This study investigated the role of Panax ginseng (PG) on the phorbol myristate acetate (PMA) + calciumionophore A23187-induced hypoxia-inducible factor-1α (HIF-1α) activation, phosphorylation of theextracellular signal-regulated kinase (ERK), and inflammatory cytokine production from the humanmast cell line, HMC-1. HIF-1α and phosphorylation of ERK were observed by Western blotting. Theinflammatory cytokine production was determined by enzyme-linked immunosorbent assay. PGinhibited the PMA+A23187-induced HIF-1α expression and the subsequent production of vascularendothelial growth factor. In addition, PG suppressed PMA+A23187-induced phosphorylation ofERK. We also show that the increased cytokines interleukin (IL)-1β, IL-6, and tumour necrosis factor-αlevel was significantly inhibited by treatment of PG. In the present study, we report for the first timethat PG is an inhibitor of HIF-1α and cytokines on the mast cell-mediated inflammatory responses.


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