Antibacterial, cytotoxic and neuropharmacological activities of Cerberaodollam seeds > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: June 19, 2007

Journal: Pages 323-328

December 2008 | Antibacterial, cytotoxic and neuropharmacological activities of Cerberaodollam seeds…

F Ahmed1,*, R Amin2, IZ Shahid1 and MME Sobhani2

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Summary

​The MeOH extract of seeds of Cerbera odollam Gaertn. (Apocynaceae) was screened for its antibacterial,cytotoxic and neuropharmacological activities. The extract showed moderate anti-bacterialactivity against Salmonella typhi, Streptococcus saprophyticus, and Streptococcus pyogenes. It exhibitedhigh level cytotoxicity against brine shrimp (LC50: 3 µg/ml). The extract potentiated pentobarbitalinduced sleeping time in mice which was further supported by the exploratory behavior test atdose of 25 mg/kg. The overall results tend to suggest the antibacterial, cytotoxic and CNSdepressant activities of the extract.


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