The aim of the study is to investigate the antioxidant activity through, reducing power, 2, 2-diphenyl-1-picryl hydrazyl radical (DPPH), nitric oxide radical (NO), superoxide radical,hydrogen peroxide radical (H2O2) scavenging activity and the amount of total phenoliccompounds of chloroform, ethyl acetate, methanol and aqueous extracts of the leaves of Talinumportulacifolium. Chloroform extract of leaves of T. portulacifolium showed highest antioxidantactivity, with a direct relationship between activity and concentration of extracts (15 - 240 µg/mL).Among all the extracts, the highest amount of the total polyphenolic compounds was found in thechloroform extract. Chloroform extract of T. portulacifolium showed an important free radicalscavenging activity towards the DPPH, NO, Superoxide and H2O2 radicals, with IC50 values of133.26, 165.75, 156.34 and 135.29 µg/mL, respectively. In the lipid peroxidation assay, extracts ofchloroform and ethyl acetate showed a remarkable inhibitory activity. The extracts showedsignificant activity in all the experiments but lower than the standard antioxidant, ascorbic acid.