Effect of an herbal formulation on DOCA-salt and fructose induced models ofhypertension in rats > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: August 16, 2007

Journal: Pages 354-364

December 2008 | Effect of an herbal formulation on DOCA-salt and fructose induced models ofhypertension in rats…

CL Athare, M Mohan* and SB Kasture

첨부파일

Summary

​The present study was carried out to investigate the antihypertensive effect of a folklore herbalformulation (HF) (300mg/kg/day; p.o.) in deoxycorticosterone acetate (DOCA)-salt induced andfructose induced hypertensive rats. In DOCA model, DOCA (15 mg/kg, s.c., twice a week) wasadministered to unilateral nephrectomized rats for 4 weeks. In fructose model, drinking waterwas replaced with 10% fructose solution for 6 weeks to induce hypertension. Systolic bloodpressure (BP) was measured once every week during the treatment schedule. After completion oftreatment schedule, BP and vascular reactivity to various agonists like Noradrenaline,Adrenaline, Phenylephrine and Serotonin (5-hydroxytrptamine; 5-HT) were recorded in rats ofboth models. A cumulative concentration response curve of 5-HT was carried out in isolated ratfundus strip of the DOCA-salt induced and fructose induced hypertensive rats. The results tendto suggest that HF possesses antihypertensive activity.


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