Nootropic Potential of Murraya koenigii leaves in Rats > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: August 27, 2007

Journal: Pages 365-373

December 2008 | Nootropic Potential of Murraya koenigii leaves in Rats…

Mani Vasudevan1,*, Milind Parle2, Singaravel Sengottuvelu1 and Thulasimani Shanmugapriya3

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Summary

​Murraya koenigii leaves commonly known as ‘curry patta’ are routinely added to Indian gravy andvegetarian dishes by south Indian as a favourate condiment. The present study was undertaken toinvestigate the effects of Murraya koenigii leaves (MKL) on memory in rats. Elevated plus-maze andHebb-Williams maze served as the exteroceptive behavioral models for testing memory. Diazepam-,scopolamine- and ageing-induced amnesia served as the interoceptive behavioral models. MKL fedorally to various groups of young and aged rats with diet containing 2, 4 and 8% w/w of MKL for 30days consecutively were investigated. The MKL diets produced a significant dose-dependentimprovement in memory scores of young and aged rats and significantly reduced the amnesiainduced by scopolamine (0.4 mg/kg, i.p.) and diazepam (1 mg/kg, i.p.). Therefore, it would beworthwhile to specifically investigate the therapeutic potential of MKL in the management ofdementia patients.


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