Preliminary study on the central nervous system depressant effect ofPicrorhiza kurrooa Royle. (Scrophulariaceae) in mice models > Volume 08 - 2008

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Oriental Pharmacy and Experimental Medicine
Volume 08 - 2008
Date: June 05, 2007

Journal: Pages 448-451

December 2008 | Preliminary study on the central nervous system depressant effect ofPicrorhiza kurrooa Royle. (Scrophulariaceae) in mice models…

Tasmina Rahman1, Khandaker Ashfaqur Rahman1, Sultana Rajia1,*, Mahiuddin Alamgir2,4,Mahmud Tareq Hassan Khan3 and M Shahabuddin Kabir Choudhuri1

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Summary

​Picrorhiza kurrooa Royle. is a well known medicinal plant among the indigenous medical practitionersof India. Present study is the first time to report the activity on the central nervous system.Preliminary study of the hot water extract showed significant depressant activity on the holeboard test as evidenced from the ambulation and head dipping scores. The extract showed betteractivity compared to diazepam on the duration of pentobarbital induced sleeping time.


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