The protective effect of anti-oxidant in cadmium-induced hair cell death > Volume 09 - 2009

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Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: March 04, 2009

Journal: Pages 285-291

December 2009 | The protective effect of anti-oxidant in cadmium-induced hair cell death…

Su-Jin Kim1,3, No-Yil Myung1, Hyun-Ja Jeong2, Jae-Young Um1, Hyung-Min Kim1 and Seung-HeonHong3,*

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Summary

​Cadmium (Cd2+) is a heavy metal and a potent carcinogen implicated in tumor developmentthrough occupational and environmental exposure. However, the auditory effect of Cd2+ is notpoorly understood. The purpose of the present study was to investigate whether prevent theototoxic effects of Cd2+ by antioxidnat in auditory cell line, HEI-OC1. Rosmarinic acid is anaturally occurring phenolic compound and also known to possess marked antioxidantproperties. We showed that antioxidnat inhibited the the cytochrome c release induced by Cd2+.In addition, we showed that the regulatory effect of antioxidnat on apoptosis is through thecaspase-9 activation, and extracellular signal-regulated kinase activation in auditory cells. Theseresults suggested antioxidnat its therapeutic usefulness, against Cd2+ induced activation ofcaspase-9 and ERK.


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