Antisteroidogenic activity of Raphanus sativus seed extract in female albinomice > Volume 09 - 2009

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Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: July 03, 2008

Journal: Pages 303-306

December 2009 | Antisteroidogenic activity of Raphanus sativus seed extract in female albinomice…

PK Haldar*, UK Mazumder, Sanjib Bhattacharya, L Manikandan and Siladitya Bhattacharya

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Summary

​The defatted methanol extract of Raphanus sativus Linn. (Cruciferae) seed (MERS) was evaluatedfor its antisteroidogenic potential in mature female Swiss albino mice. The methanol extract at thedoses of 100 and 200 mg/kg body weight significantly elevated the levels of cholesterol andascorbic acid contents which serve as a precursor for the synthesis of steroid hormones in ovaries.The extract also significantly inhibited glucose-6-phosphate dehydrogenase and Δ5-3β-hydroxysteroid dehydrogenase, the two key enzymes involved in ovarian steroidogenesis. Hence theextract (MERS) exhibited significant antisteroidogenic activity.


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