Medicinal herbs are significant source of synthetic and herbal drugs. In the commercial market,medicinal herbs are used as raw drugs, extracts or tinctures. Isolated active constituents are usedfor applied research. For the last few decades, phytochemistry (study of plants) has been makingrapid progress and herbal products are becoming popular. According to Ayurveda, the ancienthealing system of India, the classical texts of Ayurveda, Charaka Samhita and Sushruta Samhitawere written around 1000 B.C. The Ayurvedic Materia Medica includes 600 medicinal plantsalong with therapeutics. Herbs like turmeric, fenugreek, ginger, garlic and holy basil are integralpart of Ayurvedic formulations. The formulations incorporate single herb or more than two herbs(poly-herbal formulations). Medicinal herb contains multitude of chemical compounds likealkaloids, glycosides, saponins, resins, oleoresins, sesquiterpene, lactones and oils (essential andfixed). Today there is growing interest in chemical composition of plant based medicines. Severalbioactive constituents have been isolated and studied for pharmacological activity. R. cordifolia isan important medicinal plant commonly used in the traditional and Ayurvedic system ofmedicine for treatment of different ailments. This review illustrates its major constituents,pharmacological actions substantiating the claims made about this plant in the traditional systemof medicine and its clinical applications.