We have evaluated the effect of long term treatment of Enicostemma littorale (E. littorale) in type 2diabetic patients taking pills of aqueous extract of E. littorale regularly as a complimentary medicinefor at least 9 months. The effects of E. littorale on glycemic control, lipid profile, cardiac functionand DNA damage in these patients were compared with those who had not been regular intaking E. littorale but regular in taking other conventional anti-diabetics. Our data suggest that, E.littorale can maintain normal blood glucose, serum insulin, serum triglycerides levels of type 2diabetic patients if taken regularly. E. littorale also improves insulin sensitivity, and normalizedisturbed lipogram and elevated creatinine levels, thereby produces beneficial effect inpreventing cardiovascular complications and may preserve the kidney function. The finding thatE. littorale also prevents DNA damage suggest a long term effect in diabetic patients. E. littoralethus can be considered as safe supplementary therapy for a long term and effective managementof type 2 diabetic patients.