A pentacyclic triterpenoid possessing analgesic and anti-inflammatoryactivities from the fruits of Dregea volubilis > Volume 09 - 2009

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Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: January 19, 2009

Journal: Pages 315-319

December 2009 | A pentacyclic triterpenoid possessing analgesic and anti-inflammatoryactivities from the fruits of Dregea volubilis…

M Biswas1,*, K Biswas2, AK Ghosh3 and PK Haldar4

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Summary

​In present study evaluate the analgesic and anti-inflammatory activity of the compound obtainedfrom the petroleum ether (40 - 60°C) extract of the fruits from Dregea volubilis in Swiss albino miceand in Wister albino rats respectively. Dried and crushed fruits of Dregea volubilis were extractedby petroleum ether (40 - 60°C), the proper solvent system was developed by TLC and subjected tocolumn chromatography for obtaining the pure compound/s. IR, MASS, NMR (PMR, C13 NMRand DEPT) spectroscopic analysis were done to elucidate the structure of the compound/s. Thepetroleum ether (40 - 60°C) extract of the fruits of Dregea volubilis led to isolation of a pentacyclictriterpenoid designated as taraxerone and characterized as D- friedoolean- 14- en, 3 one.Taraxerone had been screened for analgesic activity in Swiss albino mice and anti-inflammatoryactivity in Wister albino rats at the dose of 5 mg/kg body weight orally and exhibit significantanalgesic and anti-inflammatory properties.


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