Anti-inflammatory activity of aqueous methanolic extract of Swietenia mahagoni(L.) Jacq. (Meliaceae) leaves > Volume 09 - 2009

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Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: November 22, 2007

Journal: Pages 74-82

March 2009 | Anti-inflammatory activity of aqueous methanolic extract of Swietenia mahagoni(L.) Jacq. (Meliaceae) leaves…

Roy S1, Besra SE1, Banerjee B2, Mukherjee J3 and Vedasiromoni JR1,*

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Summary

​Pharmacological investigations were carried out with aqueous methanolic extract (AME) ofSwietenia mahagoni (L.) Jacq. (Meliaceae) leaves. Acute toxicity studies revealed that the LD50 doseof AME was 600 mg/kg, i.p. AME was found to possess significant anti-inflammatory activity inacute, sub-chronic and chronic models of inflammation. AME selectively inhibited cyclooxygenase(COX)-2 activity, which is involved in arachidonic acid metabolism and biosynthesis ofprostaglandins under inflammatory conditions. Treatment with AME significantly enhanced totalperitoneal cell count and the number of macrophages in normal mice, which revealed that AMEmay also alter the immune response along with its anti-inflammatory effect. The saponins or thealkaloids present in AME may be responsible for the anti-inflammatory activity.


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