Although many species of Asparagus have been studied scientifically and shoots are used in thediet of Sardinians, there is very little literature available on the medicinal uses of Asparagusacutifolius Linn. The acetone-ethanol (1:1) extract was screened for antioxidant, anti-inflammatoryand adaptogenic activities. The extract showed good anti-oxidant activity in DPPH, hydroxylradical, and nitric oxide radical assays. The extract also exhibited anti-inflammatory activity in thecarrageenan-induced rat paw edema and adaptogenic activity in the milk induced leucocytosisassay in rats. The results of the present study suggest need to investigate other pharmacologicalactivities of Asparagus acutifolius.