Antibacterial effect of naturally occurring unsaturated fatty acids fromPrunus japonica against Propionibacterium acnes > Volume 09 - 2009

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Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: February 26, 2008

Journal: Pages 90-96

March 2009 | Antibacterial effect of naturally occurring unsaturated fatty acids fromPrunus japonica against Propionibacterium acnes…

Md Zakir Sultan, Ki-Moo Lee and Surk-Sik Moon*

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Summary

​The antibacterial activity-guided fractionation of the MeOH extract of seeds of traditionalmedicinal plant Prunus japonica resulted in the isolation of linoleic acid and cis-11-eicosenoicacids, and their methyl esters. Linoleic acid inhibited the growth of Propionibacterium acnes, theacne-causing anaerobic bacterium, but cis-11-eicosenoic acid, methyl linoleate, and cis-11-eicosenoate were found to be inactive. Together with isolated linoleic acid, authentic saturatedand unsaturated fatty acids were also tested against P. acnes with other bacteria and fungi. Most of theunsaturated fatty acids possessed anti-acne (MIC 16-128 µg/mL) and antimicrobial properties.


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