Antinociceptive and gastro-protective effect of the ethanolic extract of theflowering top of Anthocephalus Cadamba Roxb > Volume 09 - 2009

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Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: January 08, 2008

Journal: Pages 326-334

December 2009 | Antinociceptive and gastro-protective effect of the ethanolic extract of theflowering top of Anthocephalus Cadamba Roxb…

Nusrat Subhan1, SM Raquibul Hasan2, Md Mokarram Hossain2, Raushanara Akter2, MuntasirMamun Majumder2, Md Mostafizur Rahman2, Kamaluddin Ahmed2, Abdul Ghani2 and MdAshraful Alam2,*

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Summary

​The effect of alcoholic extract of Anthocephalus (A.) Cadamba Roxb. was evaluated in experimentalmodels of pain and ulcer. Hot tail flick test, hot plate test and acetic acid induced writhing testwere employed for evaluating the peripheral as well as central analgesic mechanism exerted bythe extracts. Gastroprotective activity was examined by HCl and ethanol induced gastric damagetest. Test group received crude extract 500 mg/kg showed maximum time needed for theresponse against thermal stimuli (6.26 ± 0.439 s) which is comparable to diclofenac sodium (6.56 ±0.381 s) in hot tail flick method. These experimental results also followed the experimental resultsof hot plate test where crude extract 500 mg/kg showed maximum time needed for the responseagainst thermal stimuli (4.74 ± 0.234 s) which is comparable to diclofenac sodium (5.58 ± 0.585 s).The crude extract at 500 and 250 mg/kg showed significant reduction in acetic acid inducedwrithing in mice with a maximum effect of 68.026% reduction at 500 mg/kg dose which is comparableto standard diclofenac sodium (79.93%). In gastroprotective study the extract of A. Cadamba (250 and 500mg/kg) significantly inhibited ulceration induced by both HCl and ethanol dose dependently. Resultsof the study suggest that the extract possesses both analgesic and gastroprotective activity on mice.


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