The antioxidant potency of methanolic extract Clerodendrum infortunatum Linn. (MECI), which arewidely used in the Indian indigenous system of medicine for different purposes, was studied. Theantioxidant potential was evaluated using different established in vitro antioxidant tests viz.determination of total amount of polyphenolics compounds, DPPH (1,1-diphenyl-2-picrylhydrazyl)radical scavenging, nitric oxide scavenging, superoxide anion radical scavenging, hydroxylradical scavenging and reductive power assay. It was found that MECI contain a high amount ofpolyphenolics and possesses significant free radical scavenging activity in all the assay. Thehigher activity was may be due to presence of richest amount of polyphenolics and flavonoids in it.