Anxiolytic effect of leaf galls extracts of Pipernigrum Linn. in Swiss Albinomice > Volume 09 - 2009

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Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: October 19, 2007

Journal: Pages 142-148

June 2009 | Anxiolytic effect of leaf galls extracts of Pipernigrum Linn. in Swiss Albinomice…

Rajesh R1,*, Sathiyanarayanan L2, Arulmozhi S3 and Ruby4



​Anxiety disorders are one of the serious problems which need proper therapy devoid of sideeffects of presently available medicines. The present study evaluates the anxiolytic and sedativeactivity of leaf galls of Piper nigrum Linn. in Swiss Albino mice. The pet. ether, chloroform, ethylacetate and ethanol extracts of leaf galls of Piper nigrum Linn were obtained by continuous soxhletextraction. The prepared extracts were found to be safe up to 2000 mg/kg body weight of mice inthe acute toxicity study. Each extract was assessed for anxiolytic activity in Swiss Albino mice byelevated plus Maze, open field test, rota rod test and phenobarbitone induced sleeping time test.In the Elevated Plus Maze test, the pet.ether extract and chloroform extract at a dose of 50 mg/kgb.w. orally, significantly (P < 0.01) increased the number of entries and time spent in open armcomparable with standard diazepam at the dose of 10 mg/kg. b.w. p.o. In the open field test, pet.ether extract (50 mg/kg b.w. p.o.) showed significant increase (P < 0.01) in ambulation andactivity in the center. Chloroform extract (50 mg/kg b.w p.o.) was significant (P < 0.05) for bothambulation and center activity. Pet. ether extract (50 mg/kg b.w. p.o) also showed significantactivity (P < 0.01) in rota rod test. All the results are comparable with standard diazepam at thedose of 1 mg /kg b.w, p.o. Moreover all the extracts showed significant (P < 0.01) increase in thephenobarbitone induced sleeping time among which pet.ether showed more prominent activity(36%) comparable with control. The results revealed that, the active pet.ether extract andchloroform extract of leaf galls of Piper nigrum Linn is worthwhile to develop the bioactiveprinciple for anxiolytic activity.

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