Suppressive effect of Spirulina fusiformis in relation to lysosomal acid hydrolases,lipid peroxidation, antioxidant status, and inflammatory mediator TNF-alphaon experimental gouty arthritis in mice > Volume 09 - 2009

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Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: April 08, 2008

Journal: Pages 164-173

June 2009 | Suppressive effect of Spirulina fusiformis in relation to lysosomal acid hydrolases,lipid peroxidation, antioxidant status, and inflammatory mediator TNF-alphaon experimental gouty arthritis in mice…

MahaboobKhan Rasool1,*, EvanPrince Sabina2, Pichandy Nithya2 and Kumar Lavanya2

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Summary

​The anti-inflammatory effect of Spirulina fusiformis on monosodium urate crystal-induced inflammation inmice has been investigated and compared with the non-steroidal anti-inflammatory drugIndomethacin. The paw volume, lysosomal enzyme activities, lipid peroxidation, anti-oxidantstatus and inflammatory mediator tumour necrosis factor-α were studied in control andmonosodium urate crystal-induced mice after oral administration of Spirulina platensis in anexperimental model for gouty arthritis. In the induced mice, the levels of lysosomal enzymes,inflammatory mediator tumour necrosis factor-α, lipid peroxidation and the paw volumeincreased significantly, whereas the antioxidant status decreased when compared to control mice.β-glucuronidase and lactate dehydrogenase level were also found to be increased in untreatedmonosodium urate crystal-incubated polymorphonuclear leucocytes. After the oral administration ofSpirulina fusiformis, the physical and biochemical changes observed in monosodium urate crystal-induced animals were significantly restored to near normal levels. The results clearly indicatedthe anti-inflammatory role of Spirulina fusiformis, a promising drug for gouty arthritis.


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