The anti-inflammatory effect of Spirulina fusiformis on monosodium urate crystal-induced inflammation inmice has been investigated and compared with the non-steroidal anti-inflammatory drugIndomethacin. The paw volume, lysosomal enzyme activities, lipid peroxidation, anti-oxidantstatus and inflammatory mediator tumour necrosis factor-α were studied in control andmonosodium urate crystal-induced mice after oral administration of Spirulina platensis in anexperimental model for gouty arthritis. In the induced mice, the levels of lysosomal enzymes,inflammatory mediator tumour necrosis factor-α, lipid peroxidation and the paw volumeincreased significantly, whereas the antioxidant status decreased when compared to control mice.β-glucuronidase and lactate dehydrogenase level were also found to be increased in untreatedmonosodium urate crystal-incubated polymorphonuclear leucocytes. After the oral administration ofSpirulina fusiformis, the physical and biochemical changes observed in monosodium urate crystal-induced animals were significantly restored to near normal levels. The results clearly indicatedthe anti-inflammatory role of Spirulina fusiformis, a promising drug for gouty arthritis.