Anti-cancer effect of Eriocaulon sieboldianum through the activation ofcaspase-3 in human leukemia cell line, HL-60 cells > Volume 09 - 2009

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Oriental Pharmacy and Experimental Medicine
Volume 09 - 2009
Date: May 04, 2009

Journal: Pages 186-191

June 2009 | Anti-cancer effect of Eriocaulon sieboldianum through the activation ofcaspase-3 in human leukemia cell line, HL-60 cells…

Su-Jin Kim1,a, Gi-Tak Lee2,a, Bo-Ra Lee2, Kwon-Su Jeon1, Hong-Kun Rim1, Jun-Ho Bang1, Yang-Gwi Kim1, No-Yil Myung1, Phil-Dong Moon1, Na-Hyung Kim1, In-Young Choi1, Young-jin Choi3,In-Cheol Kang3, Jae-Young Um1, Seung-Heon Hong2, Hyung-Min Kim1 and Hyun-Ja

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Summary

​Eriocaulon sieboldianum (ES) is used in traditional oriental medicine for various medicinalpurposes including headache, toothache, and inflammation. However, the anti-cancer effect ofthe ES is still not fully understood. In the present study, the human leukemia cell line HL-60 wasused to characterize the apoptotic effects of ES. ES induced cytotoxicity of HL-60 cells in a dose-and time-dependent manner. ES induced the generation of reactive oxygen species, and therelease of cytochrome c in a dose-dependent manner. In addition, we showed that ES-inducedapoptosis was accompanied by activation of caspase-3. Taken together, our results demonstratethat ES possesses anti-cancer activity in HL-60 cells.


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