The present study deals with the amelioration by Lagerstroemia speciosa Linn. leaf extract againsthepatotoxicity induced by carbon tetrachloride (CCl4), which was evaluated in terms of serummarker enzymes like serum glutamate pyruvate transaminase, serum glutamate oxaloacetatetransaminase, alkaline phosphatase, serum total bilirubin, total protein levels along withconcomitant hepatic and antioxidants like superoxide dismutase, catalase, glutathione, glutathioneperoxidase and lipid peroxidation enzymes were monitored. These biochemical parametersaltered by the single dose level of CCl4 (0.75 ml/kg body weight, i.p). Pre treatment with L. speciosa priorto the administration of CCl4, at the doses of 50 and 250 mg/kg. body weight/day, p.o. for 7 days,significantly restored all the serum and liver tissue parameters near to the normal levels,respectively. Silymarin was used as a reference standard, prior to the administration of CCl4 torats. These findings indicate the protective potential of L. speciosa against hepato toxicity whichpossibly involve mechanism related to its ability of selective inhibitors of (reactive oxygen specieslike antioxidants brought about significant inhibition of TBARS suggesting possible involvementof O2·-, HO2·, and ·OH. In conclusion, the amelioration may be attributed to the synergistic effectsof its constituents rather than to any single factor as the leaves are rich in tannins, sterols,flavonoids, saponins etc.